Disseminating PCOR Evidence for Long COVID Care into Practice Through Up-to-Date Clinical Decision Support | RFA HS 25 001

Opportunity Information: Apply for RFA HS 25 001

The Agency for Health Care Research and Quality (AHRQ) is offering a discretionary grant opportunity titled "Disseminating PCOR Evidence for Long COVID Care into Practice Through Up-to-Date Clinical Decision Support," released as Funding Opportunity Number RFA-HS-25-001 (CFDA 93.226). The central goal is to move patient-centered outcomes research (PCOR) evidence about Long COVID care out of journals and into day-to-day clinical workflows by using clinical decision support (CDS) tools. A defining feature of the program is that the CDS must not be static; it is expected to be maintained and consistently updated as clinical best practices evolve and new evidence emerges, so frontline clinicians are not relying on outdated guidance when treating patients with Long COVID.

In practical terms, the opportunity is focused on dissemination and implementation rather than basic research. The funding is aimed at efforts that translate PCOR findings into actionable, point-of-care guidance that clinicians can use while making real-time decisions. Because Long COVID care is rapidly changing, AHRQ is emphasizing approaches that can keep guidance current, which often implies establishing processes and governance for evidence surveillance, review, and timely updates to CDS content. The overall intent is to improve the consistency, quality, and patient-centeredness of Long COVID care by embedding evidence-based recommendations directly into clinical practice environments where decisions are made.

Eligibility is broad and includes many types of U.S.-based organizations and governments. Eligible applicants include state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; Native American tribal governments that are federally recognized; Native American tribal organizations other than federally recognized tribal governments; public housing authorities and Indian housing authorities; nonprofit organizations (both 501(c)(3) and non-501(c)(3), excluding institutions of higher education in those nonprofit categories as specified); for-profit organizations other than small businesses; small businesses; and other eligible entities. The notice also explicitly highlights additional eligible applicant types such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISISs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible agencies of the federal government, regional organizations, Indian/Native American Tribal Governments other than federally recognized, and U.S. territories or possessions.

Foreign participation is clearly restricted. Non-domestic (non-U.S.) entities (foreign organizations) are not eligible to apply, and non-domestic components of U.S. organizations are also not eligible to apply. This means the applicant organization and the components carrying out the work must be based in the United States (including U.S. territories or possessions, which are included as eligible).

The application deadline listed for this opportunity is April 10, 2025, and the posting indicates it was created on January 10, 2025. The funding instrument is a grant, and the activity category is health. The source information provided does not specify an award ceiling or the expected number of awards, so prospective applicants would need to consult the full NOFO for the budget limits, period of performance, and the number and size of awards AHRQ anticipates making.

Overall, the opportunity can be read as AHRQ seeking projects that can operationalize Long COVID PCOR evidence through CDS in a way that is usable at the point of care and designed for continuous updating. The key differentiator is the emphasis on maintaining up-to-date CDS content as evidence changes, which reflects the reality that Long COVID diagnosis, management, and patient needs are still being actively refined across clinical settings.

• The Agency for Health Care Research and Quality in the health sector is offering a public funding opportunity titled "Disseminating PCOR Evidence for Long COVID Care into Practice Through Up-to-Date Clinical Decision Support" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.226.
• This funding opportunity was created on 2025-01-10.
• Applicants must submit their applications by 2025-04-10. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for RFA HS 25 001

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